Publications

Please click here for a complete and updated list of publications.

2025

Sakano K, Sakano Y, Hurrell B.P., Kazemi MH, Li X, Shen S, Akbari O. Targeting CD48 Ameliorates ILC2-mediated Airway Hyperreactivity by Disrupting the PKCβ Pathway. Am J Respir Cell Mol Biol.
Sakano Y, Sakano K, Hurrell B.P., Kazemi MH, Li X, Shen S, Akbari O. ICOS regulates IL-10 production in group 2 innate lymphoid cells via cholesterol and cortisol biosynthesis. Journal of Clinical Investigation.
Quach C, Li X, Shafiei-Jahani P, Li M, Shen S, Helou DG, Hurrell B.P., Soroosh P, Akbari O. BTLA agonist attenuates Th17-driven inflammation in a mouse model of steroid-resistant asthma. Frontiers in Immunology.
Kazemi MH, Momeni-Varposhti Z, Li X, Hurrell B.P., Sakano Y, Shen S, Shafiei-Jahani P, Sakano K, Akbari O. FOXO1 pathway activation by VISTA immune checkpoint restrains pulmonary ILC2 functions. Journal of Clinical Investigation.

2024

Goris M, Passelli K, Peyvandi S, Díaz-Varela M, Billion O, Prat-Luri B, Demarco B, Desponds C, Termote M, Iniguez E, Dey S, Malissen B, Kamhawi S, Hurrell B.P., Broz P, Tacchini-Cottier F. NLRP1-dependent activation of Gasdermin D in neutrophils controls cutaneous leishmaniasis. PLoS Pathogens.
Sakano Y, Sakano K, Hurrell B.P., Shafiei-Jahani P, Kazemi MH, Li X, Shen S, Barbers R, Akbari O. SIRPα engagement regulates ILC2 effector function and alleviates airway hyperreactivity via modulating energy metabolism. Cell Molecular Immunology.
Shafiei-Jahani P, Yan S, Kazemi MH, Li X, Akbari A, Sakano K, Sakano Y, Hurrell B.P., Akbari O. CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus. Cell Reports.
Hurrell B.P., Sakano Y, Shen S, Helou DG, Li M, Shafiei-Jahani P, Kazemi MH, Sakano K, Li X, Quach C, Barbers R, Akbari O. Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function. Science Translational Medicine.
Hurrell B.P., Shen S., Li X., Sakano Y., Kazemi MH, Shafiei-Jahani P., Sakano K. Ghiasi H., Akbari O. Piezo1 Channels Restrain ILC2s and Regulate the Development of Airway Hyperreactivity. Journal of Experimental Medicine.
Li Y, Wu C, Lee J, Ning Q, Lim J, Eoh H, Wang S, Hurrell B.P., Akbari O, Ou JJ. Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages. PLoS Pathogens.
Sakano Y, Sakano K, Hurrell B.P., Helou DG, Shafiei-Jahani P, Kazemi MH, Li X, Shen S, Hilser JR, Hartiala JA, Allayee H, Barbers R, Akbari O. Blocking CD226 regulates type 2 innate lymphoid cell effector function and alleviates airway hyperreactivity. Journal of Allergy and Clinical Immunology.

2023

Quach C, Helou DG, Li M, Hurrell B.P., Howard E, Shafiei-Jahani P, Soroosh P, Ou JJ, Razani B, Rehan V, Akbari O. Enhancing autophagy in CD11c⁺ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome. Cell Reports.
Helou DG, Quach C, Hurrell B.P., Li X, Li M, Akbari A, Shen S, Shafiei-Jahani P, Akbari O. LAIR-1 limits macrophage activation in acute inflammatory lung injury. Mucosal Immunology.
Howard E, Hurrell B.P., Helou DG, Shafiei-Jahani P, Hasiakos S, Painter J, Srikanth S, Gwack Y, Akbari O. Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models. Nature Communications.
Helou D.G., Quach C., Fung M., Painter J.D., Hurrell B.P., Eddie Loh Y.H., Howard E., Shafiei-Jahani P., Soroosh P., Sharpe A.H., Akbari O. Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells. Journal of Allergy and Clinical Immunology.

2022

Hurrell B.P., Helou D.G., Howard E., Painter J.D., Shafiei-Jahani P., Sharpe A.H., Akbari O. PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability. Nature Communications.
Hurrell B.P., Helou D.G., Shafiei-Jahani P., Howard E., Painter J.D., Quach C., Akbari O. Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivity. Journal of Allergy and Clinical Immunology.
Galle-Treger L., Helou D.G., Quach C., Howard E., Hurrell B.P., Muench G.R.A., Shafiei-Jahani P., Painter J.D., Iorga A., Dara L., Emamaullee J., Golden-Mason L., Rosen H.R., Soroosh P., Akbari O. Autophagy impairment in liver CD11c⁺ cells promotes non-alcoholic fatty liver disease through production of IL-23. Nature Communications.
Helou D.G., Shafiei-Jahani P., Hurrell B.P., Painter J.D., Quach C., Howard E., Akbari O. LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity. Journal of Allergy and Clinical Immunology.

2021

Howard E., Hurrell B.P., Helou D.G., Quach C., Painter J.D., Shafiei-Jahani P., Fung M., Gill P.S., Soroosh P., Sharpe A.H., Akbari O. PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma. Frontiers in Immunology.
Shafiei-Jahani P.., Helou D.G., Hurrell B.P., Howard E., Quach C., Painter J.D., Galle-Treger L., Li M., Loh Y.E., Akbari O. CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma. Nature Communications.
Shafiei-Jahani P., Helou D.G., Hurrell B.P., Galle-Treger L., Howard E., Quach C., Painter J.D., Fung M., Lo R., Allayee H., Akbari O. CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation. Mucosal Immunology.
Howard E, Lewis G, Galle-Treger L, Hurrell B.P., Helou DG, Shafiei-Jahani P, Painter J, Muench GA, Soroosh P, Akbari O. IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism and ameliorates airway hyperreactivity. Journal of Allergy and Clinical Immunology.

2020

Hurrell B.P., Howard E., Galle-Treger L., Helou D.G., Shafiei-Jahani P., Painter J., Akbari O. Distinct roles of LFA-1 and ICAM-1 on ILC2s control lung infiltration, effector functions and development of AHR. Frontiers in Immunology.
Shafiei-Jahani P, Hurrell B.P., Galle-Treger L, Helou DG, Howard E, Painter J, Lo R, Lewis G, Soroosh P, Akbari O. DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus. Nature Communications.
Helou DG, Shafiei-Jahani P, Lo R, Howard E, Hurrell B.P., Galle-Treger L, Painter JD, Lewis G, Soroosh P, Sharpe AH, Akbari O. PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity. Nature Communications.
Regli I.B., Martinez-Salazar B., Passelli K., Amore J., Hurrell B.P., Muller A.J., Tacchini-Cottier F. TLR7 sensing by neutrophils is critical for the control of cutaneous leishmaniasis. Cell Reports.
Han Y., Jia Q., Shafiei-Jahani P., Hurrell B.P., Pan C, Huang P., Gukasyan J., Woodward N.C., Eskin E., Gilliland F., Akbari O., Hartiala J.A., Allayee H. Large-scale Genetic Analysis Identifies 66 Novel Loci for Asthma. Nature Communications.
Galle-Treger L., Hurrell B.P., Lewis G., Howard E., Shafiei-Jahani P., Banie H.., Razani B., Soroosh P., Akbari O. Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function. Journal of Allergy and Clinical Immunology.

2019

Hurrell B.P, Galle-Treger L., Shafiei-Jahani P., Howard E., Helou D.G., Banie H., Soroosh P., Akbari O. TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity. Cell Reports.
Galle-Treger L., Sankaranarayanan I., Hurrell B.P., Howard E., Lo R., Maazi H., Lewis G., Banie H., Epstein A.L., Hu P., Rehan V.K., Gilliland F.D., Allayee H., Soroosh P., Sharpe A.H., Akbari O. Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes. Nature Communications.
Lewis G. Wang B., Shafiei-Jahani P., Hurrell B.P., Banie H., Aleman Muench G.R., Maazi H., Helou D.G., Howard E., Galle-Treger L., Lo R., Santosh S., Baltus A., Bongers G., San-Mateo L., Gilliland F.D., Rehan V.K., Soroosh P., Akbari O. Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation. Frontiers in Immunology.

2017

Hurrell B.P., Beaumann M., Heyde S., Regli I.B., Müller A.J., Tacchini-Cottier F. Frontline Science: Leishmania mexicana amastigotes can replicate within neutrophils. Journal of Leukocyte Biology.
Descatoire M.*, Hurrell B.P.*, Govender M., Passelli K., Martinez-Salazar B., Hurdayal R., Brombacher F., Guler R., Tacchini-Cottier F. IL-4α Signaling in Keratinocytes and Early IL-4 Production Are Disepensable for Generating a Curative T Helper 1 Response in Leishmania major-infected C57BL/6 mice. Frontiers in Immunology.

2016

Coutaz M., Hurrell B.P., Auderset F., Wang H., Siegert S., Eberl G., Ho P.C., Radtke F., Tacchini-Cottier F. Notch regulates Th17 differentitation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner. Scientific Reports.
Charmoy M., Hurrell B.P., Romano A., Lee S.H., Ribeiro- Gomes F., Riteau N., Mayer-Barber K., Tacchini-Cottier F., Sacks D.L. The Nlrp3 inflammasome, IL-1beta, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice. European Journal of Immunology.

2015

Hurrell B.P., Schuster S., Gün E., Coutaz M., Williams R., Held W., Malissen B., Malissen M., Yousefi S., Simon H.U., Muller A.J., Tacchini-Cottier F. Rapid Sequestration of Leishmania mexicana by neutrophils contributes to the development of chronic lesion. PLoS Pathogens.
Falcao S.A.*, Weinkopff T.*, Hurrell B.P., Celes F.D., Curvelo R.P., Prates D.B., Barral A., Borges V.M., Tacchini-Cottier F., Oliveira C.I. Exposure to Leishmania braziliensis triggers neutrophil activation and apoptosis. PLoS Neglected Tropical Diseases.